Computational Biology · Bioinformatics · Machine Learning · Deep Learning

Blaise
Manga Enuh

I tell Stories from Omics data Insights and genome-scale metabolic network models. I build computational tools and models at the intersection of microbial biology, multi-omics, and machine learning. PhD in Biotechnology. Research Associate Scientist at the Great Lakes Bioenergy Research Center.

About

Computational biologist and data scientist with 8+ years of experience applying machine learning, metabolic modeling, and multi-omics analysis to problems in microbial biotechnology and bioproduct development.

My work spans the full stack — from designing NGS experiments and building bioinformatics pipelines, to developing scientific software tools and training predictive models for biological systems.

I am currently completing Andrew Ng's Deep Learning Specialization and developing a lightweight transformer model for structure-function prediction in microbial proteins.

  • 20+ Peer-reviewed publications
  • 8+ Years research experience
  • International Collaborations Research funding secured
  • 3 Major projects led end-to-end

Writing

Biology Is Not Deterministic. Our Discovery Paradigm Should Not Be Either What Is a Learning System? Encoding Biological Intelligence into Digital Intelligence Genome-Scale Metabolic Models in the Age of AI Computational Biology: Thinking in Five Dimensions Building Scientific Software: The Math, The Code, The Philosophy The Evolution of Software Architecture in Science and What AI Changes Next What I'm building next I built a kinetic modeling tool: Here's what I learned. AI-in-the-Loop, Multi-agent systems. Multi-agent systems, Autoresearch, OpenClaw: What is a researcher after R&D operations are automated? Hmmmmmmmm What ESM-2 taught me about building a micro-AlphaFold

New pieces about computational biology, machine learning/AI. Putting down some rants.

Projects & Software

Python · Web In Publication

MicroKinetics Analyzer

A full-stack scientific software tool for automated fitting and extraction of microbial growth kinetic parameters from experimental data. Provides an interactive web-based interface for wet-lab scientists, enabling parameter estimation analyses not previously feasible without specialized programming expertise. Developed at the Great Lakes Bioenergy Research Center.

→ View on GitHub
PyTorch · Transformers In Development

MicroStruct Transformer

A lightweight transformer-based model for protein structure-function prediction in extremophilic microbial proteins, drawing on AlphaFold2 and ESM-2 architectures. Built on public datasets from UniProt and NCBI, focused on organisms studied in prior research including Halomonas elongata and Novosphingobium. Designed as a domain-specific, computationally accessible alternative to large-scale models.

→ View on GitHub
Metagenomics · MAGs Published

Metagenomes & MAGs from a Nutrient Removal Plant at Los Angeles and Hamptons Roads Sanitation Districts

Operating biological nutrient removal (BNR) wastewater treatment plants under low dissolved oxygen (DO) conditions can significantly reduce energy costs. This project reports on metagenomes and metagenome-assembled genomes (MAGs) obtained from samples collected at the Pomona and Hamptons Roads Water Reclamation Plant before and after a DO reduction providing a genomic window into how microbial communities adapt to shifting operational conditions.

→ GitHub Repository and Publications

Selected Publications

2026

Metagenomes and metagenome-assembled genomes from a nutrient removal plant at Los Angeles County Sanitation Districts (LACSD) that transitioned from high to low dissolved oxygen

Microbiology Resource Announcements · Enuh BM, et al.

2025

Pathogenic microbiota disrupts the intact structure of cerebral organoids by altering energy metabolism

Nature · Isik, et al.

2022

Genome Analysis of Halomonas elongata Strain 153B and Insights Into Polyhydroxyalkanoate Synthesis and Adaptive Mechanisms to High Saline Environments

Current Microbiology · Enuh BM, et al.

2024

Genome‐Scale Metabolic Modeling of Halomonas elongata 153B Explains Polyhydroxyalkanoate and Ectoine Biosynthesis in Hypersaline Environments

Biotechnology Journal · Enuh BM, et al.

→ Full publication list on Google Scholar